In the present study, we found that the mRNA and protein expression of PPAR-α and ABCA1 decreased in the HFD-induced NASH model than the control group, and also in the PA/OA-induced steatosis cell model, while KP could increase their expression both in vivo and in vitro (Supplementary Figure S3). This evidence concerns the gene PPARA and metabolic dysfunction-associated steatohepatitis.