In addition, previous works suggested that CD3+CD4+ T cells, CD3+CD8a+ T cells, DNT cells, and γδ T cells exhibit diverse functions in ischemic stroke by regulating immunological and inflammatory homeostasis (Gill and Veltkamp, 2016; Ito et al., 2019; Meng et al., 2019). This evidence concerns the gene CD8A and ischemic stroke.