TTYH2 and central nervous system cancer: tweety 2 differential expression assays also demonstrated cell and tissue type-dependent expression—RNA microarray of mouse brain glioma-associated macrophages revealed ttyh2 upregulation while RNA-Seq of human glioma biopsies showed TTYH2 downregulation (Huang et al., 2014; Papatheodorou et al., 2020).