Overall, RNA-Seq and microarray experiments provide correlations between brain cancers and one or more tweety genes while functional gene knockdowns and microscopic image analyses suggest functional associations including tweety 1’s facilitation of glioma invasiveness through tumor microtube-associated mechanisms, TTYH1-C19MC’s role in embryonal brain tumors, and TTYH3-BRAF’s role in glioma. The gene discussed is TTYH1; the disease is glioma.