TTYH3 and cystic fibrosis: Additionally, TTYH3’s involvement in cystic fibrosis is suggested by strong downregulation of mTTYH3 in intestines of cftrtumor microtubule1Cam mice, although mTTYH3 is not downregulated in cftrTgH(neoim)Hgu mice with a weaker cystic fibrosis phenotype (Braun et al., 2010).