TTYH2 and pneumococcal infection: Microarray and RNA-Seq analyses also demonstrate TTYH2 upregulation in actinic keratosis, non-dysplastic Barrett’s esophagus, juvenile idiopathic arthritis, metopic craniosynostosis, nevus sebaceous of Jadassohn, post-traumatic osteoarthritis, sagittal craniosynostosis, non-primary Sjogren syndrome, autism, and Streptococcus pneumoniae infection paired with chronic obstructive pulmonary disorder as well as downregulation in Klinefelter’s syndrome, Lyme disease, sepsis, and Streptococcus pneumoniae infection (Papatheodorou et al., 2020).