Bae et al. (2019) found that TTYH1 and TTYH2 are both responsible for generating VRAC currents in the SNU-601 gastric cancer cell line after using CRISPR-Cas9 technology to delete exon 7 of the TTYH1 gene and exons 2 and 3 of the TTYH2 gene, which reduced VRAC currents in the resulting knockout cells. The gene discussed is TTYH2; the disease is gastric cancer.