In embryonal brain tumors associated with C19MC, this fusion dysregulated and increased expression of a DNMT3B isoform—a DNA methyltransferase that is found specifically in embryonic brains and is associated with significant overexpression in pediatric brain tumors (Sin-Chan and Huang, 2014; Gowher and Jeltsch, 2018). Here, DNMT3B is linked to brain neoplasm.