Finally, microarray and RNA-Seq studies show TTYH3 upregulation in actinic keratosis, Barrett’s esophagus, Crohn’s disease, nevus sebaceous of Jadassohn, pulmonary sarcoidosis, Streptococcus pneumoniae infection paired with chronic obstructive pulmonary disorder, and ulcerative colitis as well as downregulation in influenza and Streptococcus pneumoniae infection (Rhodes et al., 2004; Papatheodorou et al., 2020). The gene discussed is TTYH3; the disease is pneumococcal infection.