Additional RNA-Seq and microarray experiments have demonstrated TTYH3 downregulation in ataxia-telangiectasia, TTYH2 upregulation in cerebral small vessel disease, and TTYH2 downregulation in pick disease and progressive supranuclear palsy (Papatheodorou et al., 2020). Here, TTYH2 is linked to cerebral small vessel disease.