Furthermore, glioblastomas with 1p/19q chromosome arms codeletions (associated with diminished glioma propagation and impaired tumor microtube formation and function) show TTYH1 and TTYH2 downregulation and TTYH3 upregulation compared to 1p/19q non-codeleted gliomas (Osswald et al., 2015; Jung et al., 2017). This evidence concerns the gene TTYH2 and central nervous system cancer.