TTYH2 and malignant colon neoplasm: RT-PCR found TTYH2 upregulation in colon cancer cell lines (Caco-2, LoVo, and DLD-1) and human colon cancer tissue, although RNA-Seq of human blood platelets from colorectal cancer patients showed TTYH2 downregulation (Toiyama et al., 2007; Papatheodorou et al., 2020).