TTYH1 and amyotrophic lateral sclerosis: Dysfunctional regulation of RNA-binding protein TDP is implicated in amyotrophic lateral sclerosis development, and the TDP-43A315T mutation is found in a subset of amyotrophic lateral sclerosis patients, suggesting a functional association between TTYH1 and amyotrophic lateral sclerosis through mechanisms associated with TDP-43A315T (Neelagandan et al., 2019).