In contrast with TTYH1, TTYH2 and TTYH3 have only been studied in breast cancer through RNA-Seq and microarray analyses with TTYH2 showing downregulation and TTYH3 showing upregulation in breast cancer-associated cells and tissues (Papatheodorou et al., 2020). The gene discussed is TTYH3; the disease is breast carcinoma.