IDH1 and glioma: The mutation of isocitrate dehydrogenase 1 (IDH-1) gene leads to the accumulation of D-2-hydroxyglutarate in glioma cells, which acts as agonist of glutamate receptors when the extracellular concentration of glutamate is not increased (Dang et al., 2009; Chen et al., 2017), contributing to hyperexcitability and seizure generation (Huberfeld and Vecht, 2016).