Other manifestations of chronic BAK exposure in eyes with glaucoma include conjunctival subepithelial inflammation and fibrosis [9, 54–56], which can reduce the success of subsequent filtering surgery [9, 57–59], as well as a higher rate of cataract surgery in eyes on long-term glaucoma therapy compared to those without such exposure [60, 61], potentially related to the known actions of BAK in increasing expression of inflammatory and apoptotic mediators in lens epithelial cells [62]. This evidence concerns the gene BAK1 and glaucoma.