However, germline variants in known high-risk predisposition genes indicate heritability in less than half of the patients, frequently attributable to pathogenic variants in CDKN2A and, much less frequently, in CDK4. Additional genes, yet to be discovered, may also contribute to melanoma susceptibility, as has been shown for pathogenic variants of POT1, BAP1, TERT, ACD, and TERF2IP associated with less than 10% of melanomas accumulated within families [2]. This evidence concerns the gene CDKN2A and melanoma.