ATM and melanoma: The association of VUS with melanoma was also present when the analysis was limited to variants located in one of the three ATM functional domains, in all cases (AF 0.013 and 0.009, OR = 1.36, 95% CI = 1.01–1.79, p = 0.0347) and in familial/MPM cases (AF 0.014 and 0.009, OR = 1.55, 95% CI = 1.08–2.15, p = 0.0129).