AR and Familial prostate cancer: The increased expression of transcription factors such as sterol regulatory binding transcription factor-1 (SREBF-1), which is responsible for regulating the expression of fatty acid and cholesterol synthesising enzymes, has also been reported.85 Metabolic reprogramming in hormone-responsive and castration-resistant AR+ models of prostate cancer is mediated by fatty acid synthase, and pharmacological inhibition of FASN with IP-9119 (Table 1) leads to the reduced expression of AR and a consequent decreased in its transcriptional activity, which ultimately compromises tumour growth.86