Elevated expression of histone lysine demethylase KDM8 in treatment induced NEPC tumours functions to reprogram metabolism towards aerobic glycolysis.60 Also, MYCN, that is involved in neuroendocrine lineage reprogramming leads to elevated histone acetylation and DNA accessibility by increasing the mitochondrial export of acetyl groups and also by upregulating the HAT-GCN5. The gene discussed is MYCN; the disease is neoplasm.