PTEN and prostate cancer: Lipogenesis generates intracellular signalling molecules along with raw materials for the production of lipid bilayers, precursors for cholesterol biosynthesis to promote intratumoural androgen synthesis and biochemical energy through β-oxidation.73–75 The increased accumulation of cholesterol as cholesteryl esters stored in cytosolic lipid droplets76 in prostate cancer cells lacking PTEN supports the role of lipid metabolism in tumour growth.