The NEPC-specific upregulation of the metabolic enzyme phosphoglycerate dehydrogenase (PHGDH) was identified in 2019 while profiling adenocarcinoma and NEPC tumours.61 Upregulation of PHGDH is the first and rate-limiting step in the serine, glycine, one-carbon pathway (SGOCP). This evidence concerns the gene PHGDH and neoplasm.