It has been suggested that the effect of statins is mainly mediated through their ability to prevent the accumulation of oncogenic AKT–AR complexes formed on lipid rafts.92 A decline in the level of prostate-specific antigen (PSA) is commonly seen upon the use of statins, which seems to indicate that there could be more at play than simply cholesterol-lowering effects.92 A detailed study on the use of statins could enhance our understanding of the processes involved in prostate carcinogenesis and potentially identify new therapeutic targets for prostate cancer. This evidence concerns the gene KLK3 and prostate carcinoma.