Lipogenesis generates intracellular signalling molecules along with raw materials for the production of lipid bilayers, precursors for cholesterol biosynthesis to promote intratumoural androgen synthesis and biochemical energy through β-oxidation.73–75 The increased accumulation of cholesterol as cholesteryl esters stored in cytosolic lipid droplets76 in prostate cancer cells lacking PTEN supports the role of lipid metabolism in tumour growth. This evidence concerns the gene PTEN and neoplasm.