AR and Familial prostate cancer: It has been suggested that the effect of statins is mainly mediated through their ability to prevent the accumulation of oncogenic AKT–AR complexes formed on lipid rafts.92 A decline in the level of prostate-specific antigen (PSA) is commonly seen upon the use of statins, which seems to indicate that there could be more at play than simply cholesterol-lowering effects.92 A detailed study on the use of statins could enhance our understanding of the processes involved in prostate carcinogenesis and potentially identify new therapeutic targets for prostate cancer.