To further confirm the oncogenic properties of CRIP1 in GC, we silenced the CRIP1 expression in AGS and BGC823 cell lines using siCRIP1 (Supplementary Fig. S1F–I) and found that the downregulation of CRIP1 led to a significant inhibition of cell proliferation (Fig. 1H–J and Supplementary Fig. S1J–L). This evidence concerns the gene CRIP1 and gastric cancer.