CRP and obesity due to melanocortin 4 receptor deficiency: Observational studies in the United States have reported that among participants with a BMI 20 kg/m2, in the regression model, those with severe periodontal disease have approximately twice the CRP levels as those in participants with no or mild periodontal disease; however, this difference diminishes with increasing BMI, and inflammation caused by periodontal disease has been reported to be completely masked by the effect of obesity upon the rise of the BMI to approximately 35 kg/m241.