In the COPD samples, genes with strong correlation coefficients with ACE2 include several interferon-induced genes (IFI6, IFIT1, IFIT2), a modulator of innate immune function (OAS1), the chemokine receptor ACKR4, a gene associated with West Nile viral infection (OASL), and the ECM regulated transcription factor SOX9. In the IPF samples, ACE2 expression is strongly correlated with the nuclear factor NXF3, the transcription factor SP4, the antiviral factor TRIM11, and the Forkhead Box Q1 (FOXQ1). The gene discussed is SP4; the disease is chronic obstructive pulmonary disease.