All of the 34 differentially expressed genes (FDR ≤ 0.1) in ACE2 + AT2 cells between CLD and control overlapped with the ACE2- cells CLD vs. control analysis (Fig. 3c), suggesting that these genes reflected the disease state and were not related to ACE2 expression. The gene discussed is ACE2; the disease is congenital secretory chloride diarrhea 1.