Finally, the analysis of the changes in gene expression from publicly available databases (Sanger CRISPR) support the down-regulation of several KDMs, specially KDM6A and KDM6B, following the knockout of SMARCA4 using CRISPR/CAS9 in a panel of human cancer cell lines (https://depmap.org/portal/depmap/) (Supplementary Fig. 4f). The gene discussed is SMARCA4; the disease is cancer.