Searching the Cancer Cell Line Encyclopedia (CCLE) we found significantly lower levels of expression of several histone demethylases (KDMs), including KDM6A and KDM6B, in SMARCA4def compared with MYCamp cells or with LC cells that are wild type for SMARCA4 and MYC (Fig. 2a and Supplementary Fig. 4a). The gene discussed is KDM6B; the disease is cancer.