CD86 and neoplasm: Next, to further verify the advantages of using Oxa(IV)@ZnPc@M, whether Oxa(IV)@ZnPc@M could re-educate tumor-associated macrophages (TAM) from tumor-promoting M2 phenotype toward tumor-killing M1 phenotype was evaluated, where M1 macrophages were denoted as CD86+CD206−F4/80+ cells, and M2 macrophages were denoted as CD86−CD206+F4/80+ cells.