None of mice in the Oxa(IV)@ZnPc@M (+) + anti-PD-L1 group exhibited visible bone metastatic tumors on day 10 post-inoculation, only 25% of the mice showed visible bone metastatic tumors on day 14 post-inoculation, indicting the growth of the re-inoculated tumors was inhibited (Fig. 8e). The gene discussed is CD274; the disease is metastatic neoplasm.