Meanwhile, H&E staining of mice tibias also displayed the least degree of bone osteolysis in Oxa(IV)@ZnPc@M (+) + anti-PD-L1 group, while the tibias of PBS (+) group developed severe osteolytic bone lesions, with a large amount of proliferative tumor cells filled in the damaged bones (Fig. 6j). This evidence concerns the gene CD274 and neoplasm.