CD86 and neoplasm: According to the result, the Oxa(IV)@ZnPc@M (+) + anti-PD-L1 treatment showed the best effect on promoting DCs maturation, with the expression of CD80 and CD86 dramatically up-regulated compared with other treatment groups (Fig. 7b and Supplementary Fig. 24), indicating the best effect on maturating and activating of DCs, which showed great potential to stimulate the subsequent tumor-specific immune response.