Notably, except that a higher population of infiltrated CD8+ T cells, the levels of CD3+CD8+IFN-γ+ T cells and CD3+CD8+TNF-α+ T cells in tumor were significantly elevated by Oxa(IV)@ZnPc@M (+) + anti-PD-L1 treatment (Fig. 9k, l and Supplementary Fig. 32). Here, TNF is linked to neoplasm.