This is, for instance, the case in the TNF pathway, where several groups used BHA to claim the requirement of ROS for TNF-induced necroptosis [4–7], a regulated form of necrosis implicated in the host defense against viral infection, but also in the pathology of various diseases, including acute kidney injury and cardiac ischemia/reperfusion [8, 9]. The gene discussed is TNF; the disease is myocardial ischemia.