TFF3 and colitis: Mashimo et al. showed that mice lacking TFF3 had impaired mucosal healing, with poor epithelial regeneration after injury20 and the same was observed following chemotherapy and radiation-induced damage.35 Here, we provide another piece of evidence that Tff3−/− mice exposed to DSS to provoke acute colonic inflammation showed more severe tissue damage, more loss of body weight, and worse tissue repair than Tff3+/− mice.