CD44s, an adhesion, and the antiapoptotic molecule are overexpressed in CRC and its expression is significantly associated with the depth of invasion and lymph node involvement.27 Our previous data suggest that CD44s are associated and co-localized with CD147 in pancreatic cancer.18 Here, we show that TFF3 binds to CD147 and enhances the interaction between CD147 and CD44s, resulting in SRC and STAT3 activation. This evidence concerns the gene TFF3 and colorectal carcinoma.