The Th17/neutrophilic endotype of asthma in smokers, ACO and obese patients might be exacerbated by the systemic inflammatory response of SARS-CoV-2 infection, which is similarly driven by Th1-related cytokines, including IFNγ, IL-6, MCP1, IP10, and IL-1β [110]. The gene discussed is IL6; the disease is asthma.