In addition to NF2, we also detected intra-tumor heterogeneous mutations in three cancer-related genes [29]: (i) a frameshift insertion variant in CTNNB1 for patient T225LE, (ii) a missense variant in the protein tyrosine phosphatase receptor PTPRT for patient T227LE (however, based on RNA-seq data, this gene does not seem to be expressed in both samples of this tumor), and (iii) a nonsense variant in the transcriptional coactivator PSIP1 for patient T333HP, to our knowledge the first mutation in this gene described for MPM (Fig. 1b). This evidence concerns the gene CTNNB1 and neoplasm.