CTNNB1 and cancer: In addition to NF2, we also detected intra-tumor heterogeneous mutations in three cancer-related genes [29]: (i) a frameshift insertion variant in CTNNB1 for patient T225LE, (ii) a missense variant in the protein tyrosine phosphatase receptor PTPRT for patient T227LE (however, based on RNA-seq data, this gene does not seem to be expressed in both samples of this tumor), and (iii) a nonsense variant in the transcriptional coactivator PSIP1 for patient T333HP, to our knowledge the first mutation in this gene described for MPM (Fig. 1b).