Multiple regression analysis with regard of diabetic foot presence (DFS) vs diabetes without foot ulcerations showed a significant positive association between male sex and DFS (B = 4.17, p < 0.0005) and a negative association between DFS and omentin (B = − 0.24; p = 0.009) and peripheral artery disease (B. − 0.13; p: = 0.002). This evidence concerns the gene ITLN1 and diabetes mellitus.