Furthermore, increased E-cadherin expression, and decreased N-cadherin, Vimentin, Snail, and Slug expression were observed in si-DLEU2 transfected cells, and decreased E-cadherin expression, and increased N-cadherin, Vimentin, Snail, and Slug expression were observed in DLEU2-OE transfected cells, which suggests that DLEU2 can promote the aggressiveness and motility of tumor cells by regulating the EMT of GC cells. The gene discussed is VIM; the disease is gastric cancer.