Furthermore, increased E-cadherin expression, and decreased N-cadherin, Vimentin, Snail, and Slug expression were observed in si-DLEU2 transfected cells, and decreased E-cadherin expression, and increased N-cadherin, Vimentin, Snail, and Slug expression were observed in DLEU2-OE transfected cells, which suggests that DLEU2 can promote the aggressiveness and motility of tumor cells by regulating the EMT of GC cells. This evidence concerns the gene CDH2 and gastric cancer.