With overall survival as the prognostic outcomes of patients with osteosarcoma, Kaplan–Meier analysis suggested that low-expressed patients showed significantly higher survival time compared to patients with high-expressed hub genes (P < 0.05), except SPP1, LAPTM5 and IGF1R, as shown in Additional file 7: Figure S6. This evidence concerns the gene LAPTM5 and osteosarcoma.