VWF and androgen insensitivity syndrome: AIS thrombi are due to atherosclerosis or cardiac embolism and result in disrupted blood flow in the brain and subsequent neurological disorder.91 A recent study showed that AIS thrombi (n=177) obtained by thrombectomy contain 2 distinct structural areas, platelet- and RBC-rich regions, that interspersed each other throughout the thrombi.44 Platelet-rich regions contained dense fibrin, platelets, VWF, leukocytes, and extracellular DNA.