VWF and androgen insensitivity syndrome: VWF, produced by megakaryocytes and endothelial cells, stabilizes factor VIII and mediates platelet adhesion, thereby supporting thrombosis.60 VWF has been detected in ex vivo thrombi from patients with MI and AIS.14,61 While the role of VWF in thrombosis through platelet activation and thrombin generation is well characterized, its presence and role(s) in thrombi require further investigation.