FH and age-related macular degeneration: Although no significant difference between AMD-affected individuals and controls (p value = 0.94) was observed for FH, AMD-affected individuals showed significantly higher concentrations of FHL-1 and all five FHR proteins than did control individuals (FHL-1, β = 0.08 and p = 4.9 × 10−4; FHR-1, β = 7.21 and p = 2.4 × 10−10; FHR-2, β = 0.74 and p = 6.0 × 10−10; FHR-3, β = 0.59 and p = 1.5 × 10−5; FHR-4, β = 0.56 and p = 1.3 × 10−3; FHR-5, β = 0.10 and p = 1.9 × 10−4) (Table 1, Figures 2A–2G).