CFHR4 and age-related macular degeneration: Although this might suggest a modest genetic colocalization between the corresponding FHR protein concentrations and AMD, it is worth noting that also the top GWAS signal of FHR-4 in our previously published study on the Cambridge samples24 showed only modest LD with the top AMD-associated variant rs10922109 [1.1] (rs61818890, R2 = 0.49).