CFHR2 and age-related macular degeneration: Associations of protein-altering low-frequency and rare variants with advanced AMD in the locus-wide conditioned analysis were found for the CFH, CFHR2, and CFHR5 (SKAT-O p values of 7.52 × 10−6, 5.03 × 10−3, and 2.81 × 10−6, respectively; Table 4).