Out of these 52 signals, a total of eight are located at an extended CFH locus, encompassing KCNT2, CFH, CFHR1, CFHR2, CFHR3, CFHR4, and CFHR5. The lead variants of these signals include only one CFH missense variant, rs121913059 (p.Arg1210Cys), which exerts a very strong effect on AMD (odds ratio [OR] = 20.28). Here, CFHR4 is linked to age-related macular degeneration.