The association between increased FHR-1 and FHR-3 concentrations and advanced AMD is in line with the previously reported protective effect of the CFHR3-CFHR1 deletion.22, 23, 24, 25, 26, 27, 28, 29 Our findings suggest that the deletion exerts its protective effect on AMD by decreased or absent FHR-1 and FHR-3 in the carriers. The gene discussed is CFHR1; the disease is age-related macular degeneration.