However, we used recently validated in-house-developed ELISAs to measure each protein and dimer specifically.32, 33, 34 Here, we measured serum concentrations of FH, FHR-1, FHR-2, FHR-3, and FHR-4, FHR-5, and the homo- and heterodimers of FHR-1 and FHR-2 in a cohort of 418 individuals, including 202 control individuals and 216 individuals with advanced AMD. Here, CFHR1 is linked to age-related macular degeneration.