The second-most common variant of the AMD GWAS, rs570618 (1.2, in high LD with rs1061170 [p.Tyr402His]), is an AMD-risk-conferring variant and was strongly associated with increased serum concentrations of total FHR-1 and FHR-2, FHR-1/1 dimers, FHR-1/2 dimers, FHR-2/2 dimers, FHR-4A, and to a lesser degree, FHR-5. The gene discussed is CFHR1; the disease is age-related macular degeneration.