FH and age-related macular degeneration: The p.Arg1210Cys and p.Tyr402His variants are reported to affect the binding properties of FH (and FHL-1 in the case of p.Tyr402His), resulting in reduced function of the protein, which in turn would lead to a more active state of the complement system and local chronic inflammation.16, 17, 18, 19, 20 The underlying effects of the other AMD-associated signals at this locus are, however, not known.