After correction for multiple testing, total FHR-1, total FHR-2, FHR-1/1 dimers, FHR-1/2 dimers, FHR-2/2 dimers, FHR-3, and FHR-4A concentrations were found to be associated with advanced AMD, and for all FHR proteins, an increase in systemic concentrations was associated with an increased risk for advanced AMD (Table S3, Figure 1). This evidence concerns the gene CFHR3 and age-related macular degeneration.