The first major susceptibility locus for AMD was identified on chromosome 1 at the 1q31.3 locus, where the rs1061170 (p.Tyr402His) variant in complement factor H (CFH) was strongly associated with an increased risk for AMD.11, 12, 13, 14 This finding soon implicated factor H (FH), a major regulator of the alternative pathway of the complement cascade, and its short splice variant FH like-1 (FHL-1) in the development of AMD. The gene discussed is FH; the disease is age-related macular degeneration.