FKRP and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: Besides FKRP, mutations in several other genes directly involved in α-DG glycosylation, such as POMT1, POMT2, LARGE, and FKTN, result in different forms of dystroglycanopathies (Beltrán-Valero de Bernabé et al., 2002; Martin, 2007).