A Japanese group observed that hyperglycaemia induced cellular hypoxia in diabetic mice and suppressed the expression of aquaporin-1 (AQP1, a water and oxygen channel which facilitates diffusion of oxygen across cell membranes) [6] while increased expression of AQP1 had a protective effect against hyperglycaemia-induced mitochondrial dysfunction, suggesting an association between alterations of transport of water and/or oxygen and mitochondrial dysfunction in high-glucose environments. This evidence concerns the gene AQP1 and Hyperglycemia.