The findings that high levels of VEGF-A are associated with increased mortality in this cohort are consistent with rs699947 having been previously implicated in the pathogenesis of CHD [47] and being a predictor independent of NT-proBNP and sFlt-1 suggests a complex regulatory network, although natriuretic peptides and VEGFA may respond to similar signalling is suggested by S1 Fig. The gene discussed is VEGFA; the disease is coronary artery disorder.