Recent studies showing that drugs that inhibit the sodium–glucose co-transport at proximal tubular levels (sodium–glucose co-transporter 2 [SGLT2] inhibitors) may offer substantial nephro- and cardioprotection to patients with type 2 diabetes and different levels of albuminuria [29,30] might pave the way to novel prevention strategies based on the integrated use of these novel medications with an ACE inhibitor or an ARB, but not with their combination. This evidence concerns the gene ACE and type 2 diabetes mellitus.