The CK1 family play key roles in many cellular processes including cell proliferation and differentiation, apoptosis, vesicular trafficking, DNA repair, mRNA processing, cytoskeleton dynamics, and circadian rhythms [31–33] On the other hand, CK2 is also a ubiquitously expressed pleiotropic protein kinase and play many major regulatory roles in several cellular processes including cell cycle, transcription, protein stability and degradation, translation, circadian rhythms, tumor progression in mammals and cell survival. This evidence concerns the gene CSNK1A1 and neoplasm.