Hyperglycemia has been found to impair cellular autophagy.[23] Furthermore; impaired autophagy has been reported to increase apoptosis of pancreatic beta cells after high-fat diet and high glucose diet in an experimental study.[24] However, we found no significant correlation between the degrees of hyperglycemia as assessed by HbA1C level and Beclin1. The gene discussed is BECN1; the disease is Hyperglycemia.