NRP1 and central nervous system cancer: Jia et al. demonstrated that labeling exosomal membrane with neuropilin-1 (NRP-1) targeting peptide (RGE peptide) by click chemistry promoted glioma targeting and BBB penetration in orthotopic glioma models, since NRP-1 was reported to be overexpressed in glioma cells and tumor vascular endothelium [91, 92].