JWH-015, an agonist of the CB2 receptor, in human MCF-7 mammary carcinoma cells reduced viability by inducing apoptosis independent of Gαi signalling or by pharmacological blockade of CB1, GPR55, TRPV1 or TRPA1 receptors and instead these effects were calcium-dependent and caused changes in MAPK/ERK signalling (Hanlon et al. 2016). The gene discussed is CNR1; the disease is breast carcinoma.