CASP3 and malignant colon neoplasm: In a study by Aviello et al., CBD treatment in an azoxymethane (AOM)-induced murine model of colon cancer, reduced aberrant crypt foci, polyps, tumour growth and led to a decrease in expression of inducible nitric oxide synthase (iNOS) and phosphorylated Akt with an upregulation in caspase-3 (Aviello et al. 2012).