CNR2 and breast carcinoma: Hanlon and co-workers report using JWH-015, a CB2 agonist, significantly reduced tumour burden and metastasis of murine mammary carcinoma 4T1 cells in immunocompetent mice and these effects were dependent on calcium and induced changes to MAPK/ERK signalling which were independent of G-protein-coupled signalling, CB or vanilloid receptors (McAllister et al. 2011).