Additionally, Vrechi and colleagues show CBD stimulates autophagy signal transduction via crosstalk of ERK1/2 and AKT kinases and that CBD-induced autophagy was reduced in presence of CB receptors and TRPV1 receptor antagonists, AM251, AM630 and capsazepine in neuroblastoma and murine astrocyte cell lines (Vrechi et al. 2021). Here, AKT1 is linked to neuroblastoma.