A study investigating the effects of the endogenous cannabinoid, Met-F-AEA (a metabolically stable anandamide analogue) in a highly invasive murine breast cancer model reported a significantly reduced amount and size of metastatic nodes and this effect was antagonized by the selective CB1 antagonist Rimonabant (Grimaldi et al. 2006). The gene discussed is CNR1; the disease is breast cancer.