First, the CNA profile of breast cancer was selected from the four-level hierarchy (Supplementary Figure 1b), which listed ERBB2 among the top five genes (Figure 5a) that exhibits duplication frequency of 2.06, 2.06 and 16.67% in COSMIC, CCLE and TWBC, respectively (Figure 5b). Here, ERBB2 is linked to breast carcinoma.