Moreover, the transcription of canonical Wnt target genes, such as matrix metalloproteinase (MMP) MMP-2, MMP-3, MMP-7 and MMP-9,24 is mediated after stabilization and translocation of β-catenin to the nucleus,25 and some of which were involved in the myopia through regulation of scleral collagen metabolism.26 The gene discussed is MMP3; the disease is myopia.