An accurate prognosis prediction model based on 11 DEGs (MYCL, NDRG1, IFNLR1, C1GALT1C1L, ATP6V1G3, B3GALT4, MGAT1, PFN2, IL23A, ABCA7, and MAN2B1) between hot and cold osteosarcomas was constructed and validated. The gene discussed is NDRG1; the disease is osteosarcoma.