An accurate prognosis prediction model based on 11 DEGs (MYCL, NDRG1, IFNLR1, C1GALT1C1L, ATP6V1G3, B3GALT4, MGAT1, PFN2, IL23A, ABCA7, and MAN2B1) between hot and cold osteosarcomas was constructed and validated. This evidence concerns the gene MAN2B1 and osteosarcoma.