This is connected to (a) high C‐terminal acetylation and mitochondrial localization of p53, (b) acetyl‐p53‐BAK and acetyl‐p53‐BCL‐XL complexes, (c) impaired HR and DNA repair, (d) decreased transcriptional activity of p53, (e) an imbalance in BCL2 proteins, and (f) significant intrinsic apoptosis induction in p53‐positive cancer cells. The gene discussed is TP53; the disease is cancer.