The most frequently occurring genetic event in clear cell renal cell carcinoma (ccRCC) is the deletion or inactivated mutation of the gene von Hippel-Linadau (VHL) tumor suppressor, which is involved in the ubiquitination and degradation of hypoxia-inducible factors (HIF-1α and HIF-2α) (Cancer Genome Atlas Research, 2013; Masson and Ratcliffe, 2014). This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.