Recent data suggest that HFD‐induced obesity induces a loss of trabecular bone and a reduction of cortical bone growth in mice, reflecting a state of chronic inflammation.(50) Proinflammatory cytokines, including TNF‐α, IL‐1, and IL‐6, were suggested as key mediators in the process of osteoclast differentiation and activity that lead to accelerated bone resorption(51) through the regulation of the RANKL/RANK/osteoprotegerin pathway.(52) This may explain our ex vivo nonadherent bone marrow cell culture results, in which osteoclastogenesis was increased in cells from HFD mice. This evidence concerns the gene TNFRSF11B and obesity due to melanocortin 4 receptor deficiency.