Left: 1.9 cm PHEO; 2.4 cm yellow round mass composed of clear cells, P450C17 not expressed (suggesting tumor not secreting cortisol) though all other steroid synthetases (p450SCC, 3BHSD, p450c21, and p450c11) were expressed, suggesting aldosterone production. Zona glomerulosa of normal adrenal gland showed hyperplasia with no expression of 3B-HSD, which was construed as a finding of paradoxical hyperplasia associated with aldosterone overproduction. No significant atrophy in zona fasciculata or reticularis (no HPA axis suppression so likely no long-term cortisol production). The gene discussed is CYP17A1; the disease is neoplasm.