The clinical studies have been shown that oxidative stress play an important role in the etiology of RA, also evidences demonstrated the increased level of oxidative stress biomarkers and decreased antioxidants status in RA patients [[4], [5], [6], [7], [8]] The reactive oxygen species (ROS) can cause inflammatory responses by activating nuclear factor kappa-B (NF-kB) in in RA [4]. Here, NFKB1 is linked to rheumatoid arthritis.