Besides, the expression of circ_VANGL1 and SOX4 was downregulated, while miR-145-5p was upregulated in xenograft tumor tissues with doxorubicin treatment, circ_VANGL1 knockdown, and co-treatment of doxorubicin and circ_VANGL1 knockdown (Figure 7c). The gene discussed is VANGL1; the disease is neoplasm.