Hypophosphatasia (HPP), an inherited metabolic disease characterized by deficiency of the enzyme alkaline phosphatase (ALP) is caused by pathogenic variants in the Tissue Nonspecific Alkaline Phosphatase (TNSALP) encoding gene (ALPL) (Millán and Whyte, 2016; Weiss et al., 1988). This evidence concerns the gene ALPL and Other metabolic disease.