It was reported that avocado and soybean unsaponifiables can restrain osteoarthritis through inhibition of proinflammatory cytokines such as IL-1β, IL-3, IL-6, IL-8, IL-13, and TGF-β; also, they can modulate oxidative damages by repression of ROS production [144–146]. The gene discussed is TGFB1; the disease is osteoarthritis.