In systemic sclerosis patients, the level of surface CAMs is reduced in comparison with an elevated level of soluble forms (circulating) such as the intercellular adhesion molecule 1 (ICAM-1), endothelial leukocyte adhesion molecule 1 (ELAM-1), vascular cell adhesion molecule 1 (VCAM-l), P-selectin, and E-selectin [92–94]. This evidence concerns the gene SELE and systemic sclerosis.