The lower levels of CD4 (P = 0.024) and CD19 (P = 0.020) were more common in patients younger than 70 years, and higher Borrmann type and lymph node metastasis were related to increased serum CD4 (P = 0.041, P = 0.026; Table 2). This evidence concerns the gene CD4 and metastatic malignant neoplasm in the lymph nodes.