Genes like HHEX/IDE, KCNJ11, NOTCH2, WFS1, IRS1, CAPN10, KCNQ1, HNF4A, TCF-2/HNF1B, IRS-2, and TCF7L2 have been studied to be associated with T2D in Pakistani population [22–26]. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.