IL4 and cancer: For example, IGF2BP2 inhibits UCP1 translation and series of mitochondrial polypeptides in brown adipose tissue.[41] Moreover, IGF2BP2 modulates mitochondrial activity and encodes mitochondrial respiratory chain complex subunits in glioblastoma cancer stem cells.[42] Our finding that loss of IGF2BP2 impaired OXPHOS in IL4 induced M2 macrophages provides more evidence for these early findings.