Recent report showed that IGF2BP2 stabilizes HK2 and GLUT1 mRNA to promote glycolysis in colon cancer [43] and glycolysis is necessary for M2 macrophage activation.[25] These researches show another possibility that IGF2BP2–/– macrophages have deficient functions of glucose uptake and glycolysis to support M2 polarization. The gene discussed is IGF2BP2; the disease is colonic neoplasm.