Inflammatory macrophages are implicated in the pathogenesis of ulcerative colitis development.[30] Consistent with higher levels of IGF2BP2 in LPS treated macrophages (Figure 1 and Figure S1, Supporting Information), we found that IGF2BP2 were positive in approximately half of CD68+ macrophages from ulcerative colitis patients (Figure5a). This evidence concerns the gene IGF2BP2 and ulcerative colitis.