Several oncogenic signaling pathways, including JAK/STAT, PI3K/AKT, WNT, P53, and NF‐κB, have been found to regulate cancer stemness.[16] Gene set enrichment analysis (GSEA) showed that the JAK/STAT signaling pathway‐related genes, but not PI3K/AKT, WNT, P53, and NF‐kB, were affected in SCC23 cells with circFAT1 KD (Figure 4A; Figure S4A, Supporting Information). Here, NFKB1 is linked to cancer.