PD‐L1 is known to be regulated by IFN signaling, and PD‐L1 induction suppresses the functional activity of tumor infiltrating CD8+ T cells.[22] We also found that PD‐L1 expression was upregulated in SCC23 and SCC1 with circFAT1 KD (Figure S5B, Supporting Information). This evidence concerns the gene IFNA1 and neoplasm.