HNRNPL, which is often up‐regulated in many types of solid cancer (TCGA data), plays an important role in the biogenesis of circARHGAP35, suggesting that transcriptome alterations mediated by abnormal RBPs during cancer activation and progression may give rise to oncogene activation in a way that does not rely on genomic or epigenomic variations. This evidence concerns the gene HNRNPL and cancer.