ARHGAP35, also known as p190‐A, is a member of the Rho GTPase activating protein (RhoGAPs) family, which “switches off” Rho GTPase by stimulating the GTP hydrolyzing activity of Rho and turning it to a GDP‐bound inactive state.[38] Previous studies have shown that ARHGAP35 regulates cell cycle and metastasis, and acts as a tumor suppressor gene.[22, 39] Consistent with previous reports, we have confirmed that ARHGAP35 reduces RhoA activity, decreases stress fiber formation, and suppresses cancer cell migration and invasion. The gene discussed is ARHGAP35; the disease is cancer.