ARHGAP35, also known as p190‐A, is a member of the Rho GTPase activating protein (RhoGAPs) family, which “switches off” Rho GTPase by stimulating the GTP hydrolyzing activity of Rho and turning it to a GDP‐bound inactive state.[38] Previous studies have shown that ARHGAP35 regulates cell cycle and metastasis, and acts as a tumor suppressor gene.[22, 39] Consistent with previous reports, we have confirmed that ARHGAP35 reduces RhoA activity, decreases stress fiber formation, and suppresses cancer cell migration and invasion. This evidence concerns the gene RHOA and cancer.