Recent studies on COVID-19 have suggested that the initiation of the SARS-CoV-2 infection is governed not only by ACE2/TMPRSS2 receptor binding, but also by the recognition of TLR4 on cell surface with its Spike protein[7] and TLR7 intracellularly with its ssRNA.[8] In addition, Spike protein of SARS-CoV-2 can bind to bacterial lipopolysaccharide, which is also the ligand for TLR4 stimulation.[9]. The gene discussed is TLR4; the disease is COVID-19.