In conclusion, our comprehensive study identified several exosomal-associated lncRNA/circRNA-miRNA-mRNA interaction axes (RPL7AP11/hsa-miR-17-5p/UBC and RPL7AP11/hsa-miR-20b-5p/UBC) in the progression of CHD, which may be crucial targets for disease treatment. This evidence concerns the gene RPL7AP11 and coronary artery disorder.