Likewise, elevated PAI-1 levels were significantly associated with the 4G/4G (0.003) and 4G/5G (0.0001) genotypes of 4G/5G polymorphism and GA (p < 0.0001) and AA (p-0.003) genotypes of -844G/A polymorphism in CSA cases versus control group (Table 10). This evidence concerns the gene SERPINE1 and chromosome-type aberration frequency.