NLRP1 has also been implicated in acute glaucoma; in an acute IOP elevation/glaucoma mouse model (Tlr4 -/-), it was found that TLR4 leads to increased caspase-8 expression which increases IL-1β expression and retinal ganglion cell death through a caspase-1 dependent pathway involving NLRP1 and NLRP3, as well as a caspase-1 independent pathway [118]. This evidence concerns the gene CASP1 and glaucoma.